Histopathological and Immunohistochemical Study of the Distinction between Oral Lichen Planus and Oral Lichenoid Lesions

作     者：Takehiro Suzuki Masaaki Suemitsu Mitsuko Nakayama Chieko Taguchi Masayuki Ukigaya Chiori Nakamura Yoshikazu Nakayama Hiroshi Yamamoto Kayo Kuyama Takehiro Suzuki;Masaaki Suemitsu;Mitsuko Nakayama;Chieko Taguchi;Masayuki Ukigaya;Chiori Nakamura;Yoshikazu Nakayama;Hiroshi Yamamoto;Kayo Kuyama

作者机构：Nihon University Graduate School Dentistry at Matsudo Oral Pathology Chiba Japan Department of Pathological Diagnosis Nihon University Hospital at Matsudo Chiba Japan Department of Pathology Nihon University School of Dentistry at Matsudo Chiba Japan Department of Community Oral Health Nihon University School of Dentistry at Matsudo Chiba Japan Department of Oral Surgery Nihon University School of Dentistry at Matsudo Chiba Japan 

出 版 物：《Open Journal of Stomatology》 (口腔学期刊（英文）)

年 卷 期：2021年第11卷第2期

页      面：91-106页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Oral Lichen Planus (OLP) Oral Lichenoid Lesions (OLLs) Immunohistochemical Staining CK19 COX-2 

摘      要：Background: Oral potentially malignant disorders, which include oral lichen planus (OLP), are clinical presentations that carry a risk of development to cancer in the oral cavity. Oral lichenoid lesions (OLLs) are also termed interface/lichenoid mucositis. Malignant transformation of them remains controversial, but distinct clinical and histological criteria for how to differentiate OLP from OLLs have not been developed.Objectives: The purpose of this study was to elucidate findings that can allow histopathological differentiation of OLP and OLLs using histomorphological and immunohistochemical analyses.Materials and Methods: Analyses were performed in 10 cases diagnosed with OLP and 9 cases diagnosed with OLLs. Cytokeratin 19 (CK19), Ki-67 and CD3 were used as primary antibodies to detect basal cells, proliferative activity and T-cell distribution, respectively, and Perlecan and COX-2 to evaluate epithelial intracellular arrangements and interstitial distributions of proteoglycans and enzymes. Results: For CK19, positive cells were significantly found in OLLs at both the prominent area and site adjacent to the lesion comparison with those of OLP’s. The number of COX-2 positive cells was significantly higher in spinous and basal layers in OLLs of the prominent area. Additionally, OLLs showed mild to moderate expression for perlecan in the basal to spinous layers and in subepithelial tissue. Conclusion:/s