The potential of ionic liquids in biopharmaceutical engineering

作     者：Xuan Lin Zhiguo Su Yanli Yang Songping Zhang Xuan Lin;Zhiguo Su;Yanli Yang;Songping Zhang

作者机构：State Key Laboratory of Biochemical EngineeringInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190China 

出 版 物：《Chinese Journal of Chemical Engineering》 (中国化学工程学报（英文版）)

年 卷 期：2021年第34卷第2期

页      面：236-243页

核心收录：

学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 081702[工学-化学工艺] 0817[工学-化学工程与技术] 08[工学] 0703[理学-化学] 10[医学] 

基　　金：The authors are thankful for the financial support from the National Natural Science Foundation of China(Nos.21808226 31970872 and 21821005) 

主　　题：Ionic liquids Biopharmaceutical engineering Biomacromolecules Stabilization Vaccine Delivery 

摘      要：Biopharmaceuticals,such as proteins,peptides,nucleic acids and vaccines,bring about great hopes for the prevention and treatment of various diseases,but the industrialization of these products still faces challenges such as structural instability,inefficient bioactivity and low *** liquids(ILs),the marvelous solvent media with inimitable and tunable properties,may provide alternative solutions to overcome the above problems of biopharmaceutical *** has gradually been made through studies by combination of ILs with *** applications involved the stabilization,protection,and delivery of *** trends are being forwarded to using ILs in vaccines and nucleic acid ***,challenges remain on the toxicity and safety ***,the cost of adding ILs to the benefits of biopharmaceuticals need to be considered.