Photoacoustic-immune therapy with a multi-purpose black phosphorus-based nanoparticle

作     者：Fanchu Zeng Huan Qin Liming Liu Haocai Chang Qun Chen Linghua Wu Le Zhang Zhujun Wu Da Xing Fanchu Zeng;Huan Qin;Liming Liu;Haocai Chang;Qun Chen;Linghua Wu;Le Zhang;Zhujun Wu;Da Xing

作者机构：MOE Key Laboratory of Laser Life Science&Institute of Laser Life ScienceCollege of BiophotonicsSouth China Normal UniversityGuangzhou510631China Guangdong Provincial Key Laboratory of Laser Life ScienceCollege of BiophotonicsSouth China Normal UniversityGuangzhou510631China 

出 版 物：《Nano Research》 (纳米研究（英文版）)

年 卷 期：2020年第13卷第12期

页      面：3403-3415页

核心收录：

学科分类：1002[医学-临床医学] 0808[工学-电气工程] 0809[工学-电子科学与技术（可授工学、理学学位）] 0805[工学-材料科学与工程（可授工学、理学学位）] 100214[医学-肿瘤学] 10[医学] 0702[理学-物理学] 

基　　金：This research was supported by the National Natural Science Foundation of China(Nos.11604105 and 81630046) the Science and Technology Planning Project of Guangdong Province,China(Nos.2015B020233016,2014B020215003,and 2014B050504009) the Scientific and Technological Planning Project of Guangzhou City(Nos.201805010002 and 201804010360) the Science and Technology Program of Guangzhou(No.2019050001)。 

主　　题：photoacoustic therapy mitochondrial targeting black phosphorus immunotherapy checkpoint blockade 

摘      要：Effective therapeutic strategies to precisely eradicate primary tumors with minimal side effects on normal tissue,inhibit metastases,and prevent tumor relapses,are the ultimate goals in the battle against cancer.We report a novel therapeutic strategy that combines adjuvant black phosphorus nanoparticle-based photoacoustic(PA)therapy with checkpoint-blockade immunotherapy.With the mitochondria targeting nanoparticle,PA therapy can achieve localized mechanical damage of mitochondria via PA cavitation and thus achieve precise eradication of the primary tumor.More importantly,PA therapy can generate tumor-associated antigens via the presence of the R848-containing nanoparticles as an adjuvant to promote strong antitumor immune responses.When combined with the checkpoint-blockade using anti-cytotoxic T-lymphocyte antigen-4,the generated immunological responses will further promote the infiltrating CD8 and CD4 T-cells to increase the CD8/Foxp3 T-cell ratio to inhibit the growth of distant tumors beyond the direct impact range of the PA therapy.Furthermore,the number of memory T cells detected in the spleen is increased,and these cells inhibit tumor recurrence.This proposed strategy offers precise eradication of the primary tumor and can induce long-term tumor-specific immunity.