Engineered microorganisms and enzymes for efficiently synthesizing plant natural products

作     者：Wenqiang Li Wentao Sun Chun Li Wenqiang Li;Wentao Sun;Chun Li

作者机构：Key Lab for Industrial BiocatalysisMinistry of EducationDepartment of Chemical EngineeringTsinghua UniversityBeijing 100084China 

出 版 物：《Chinese Journal of Chemical Engineering》 (中国化学工程学报（英文版）)

年 卷 期：2021年第34卷第2期

页      面：62-73页

核心收录：

学科分类：081702[工学-化学工艺] 08[工学] 0817[工学-化学工程与技术] 

基　　金：This work was supported by the National Key Research and Development Program of China(2018YFA0901800) the National Natural Science Foundation of China(No.21736002) 

主　　题：Plant natural products Microorganisms Synthetic biology Enzyme engineering 

摘      要：Plant natural products are a kind of active substance widely used in pharmaceuticals and ***,the current production mode based on plant culture and extraction suffer complex processes and severe concerns for environmental and *** the increasing awareness of environmental sustainability,engineered microbial cell factories have been an alternative approach to produce natural *** engineering strategies have been utilized in microbial biosynthesis of complex phytochemicals such as dynamic control and substructure ***,Enzyme engineering including directed evolution and rational design has been implemented to improve enzyme catalysis efficiency and stability as well as change promiscuity to expand product *** this review,we discussed recent advances in microbial biosynthesis of complex phytochemicals from the following aspects,including pathway construction,strain engineering to boost the production.