The effects of Chinese herbal medicines on Madopar dose and adverse reaction during the maintenance phase of Parkinson's disease:a systematic review with meta-analysis
作者机构：College of Traditional Chinese MedicineJinan UniversityGuangzhou 510632China Shenzhen Traditional Chinese Medicine HospitalShenzhen 518033China Shandong University of Traditional Chinese Medicinejinan 250355China
出 版 物：《TMR Aging》 (衰老研究)
年 卷 期：2020年第2卷第4期
页 面：110-122页
基 金：supported by Guangdong Basic and Applied Basic Research Foundation(2019A1515010644) Major Research and Development Program of Shandong Province,China(2018GSF118149) Project of Traditional Chinese Medicine Bureau of Guangdong Province(No.20201073)
主 题：Chinese herbal medicines Madopar Dose Adverse reaction Maintenance phase Meta-analysis
摘 要：Background:Parkinson’s disease is a progressive neurodegenerative disease,and is usually treated with levodopa combined with dopa decarboxylase inhibitor like *** order to improve the efficacy and reduce adverse reactions,Chinese herbal medicines are usually applied with Madopar to treat Parkinson’s disease in *** to the results of certain randomized controlled trials,levodopa drugs combined with Chinese herbal medicines could achieve better effects like the improvement of clinical symptoms,the reduced incidence of adverse reactions,and the reduced dose of levodopa drugs(especially in the maintenance phase).However,not all the randomized controlled trials showed favorable effect on Parkinson’s ***,it is necessary to find out how to effectively combine Chinese herbal medicines with *** order to evaluate the effects of Chinese herbal medicines on Madopar dose and adverse reaction during the maintenance phase of Parkinson’s disease,a meta-analysis was ***:A systematic research was carried out for randomized controlled trials of combined Chinese herbal medicines and Madopar treatment for Parkinson’s disease during the maintenance phase published till August *** primary outcome was the Madopar dose and secondary outcome was the incidence of adverse *** were pooled and analyzed with RevMan ***:A total of 18 studies were included with 1,169 ***,study quality evaluation showed low methodological ***-analyses showed that the dose of Madopar in the treatment group was significantly lower than that in the control group,and the incidence of adverse reactions in the treatment group was also significantly lower than that in the control ***,the correlation analysis showed that the reduction of Madopar dose was not related to the reduction of incidence of adverse reactions(P0.05).There existed publication bias on the primary outcome and secondary ***:Chinese h
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