The methylenetetrahydrofolate reductase genotype 677CT and non-alcoholic fatty liver disease have a synergistic effect on the increasing homocysteine levels in subjects from Chongqing,China

作     者：Xiaolin Wang Yongli Zhou Mingjun Zhang Yonghong Wang Bo Qin 

作者机构：Health Management CenterThe First Affiliated Hospital of Chongqing Medical UniversityChongqingChina Department of NeurologyThe First Affiliated Hospital of Chongqing Medical UniversityChongqingChina Department of Infectious DiseasesThe First Affiliated Hospital of Chongqing Medical UniversityChongqingChina 

出 版 物：《Genes & Diseases》 (基因与疾病（英文）)

年 卷 期：2019年第6卷第1期

页      面：88-95页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 0703[理学-化学] 10[医学] 

基　　金：This study was funded by a grant from the ChongQing Science and Technology Commission(grant no.cstc2015jcsf10012-03) 

主　　题：Gene polymorphism Homocysteine Methylenetetrahydrofolate reductase Nonalcoholic fatty liver disease Synergistic effect 

摘      要：The methylenetetrahydrofolate reductase(MTHFR)genotypes 677CT and 677TT are associated with elevated serum homocysteine(Hcy)levels by means of lowering the activity of MTHFR,and the increase in serum Hcy may be linked to increased susceptibility to nonalcoholic fatty liver disease(NAFLD).However,there are contradictory reports of the relationship among the MTHFR 677CT gene polymorphism,Hcy,and ***,the aim of this study was to identify potential associations and interactions of either Hcy levels or the MTHFR 677CT gene polymorphism with the susceptibility to NAFLD in a Chinese *** association between the MTHFR 677 CT gene polymorphism and Hcy levels was determined in 243 subjects with NAFLD and 388 healthy subjects without NAFLD using polymerase chain reactionrestriction fragment length polymorphism analysis and high-performance liquid *** subjects with NAFLD,there was no statistical difference in the genotypic and allelic frequencies of the MTHFR 677 CT gene polymorphism,while serum Hcy levels were significantly higher in subjects with ***,these results strongly suggest that the MTHFR 677CT gene polymorphism and NAFLD have a potential synergistic effect on Hcy elevation,although the MTHFR 677CT gene polymorphism was not correlated with NAFLD in a Chinese population.