Identification of four novel prognosis biomarkers and potential therapeutic drugs for human colorectal cancer by bioinformatics analysis

作     者：Zhen Sun Chen Liu Steven Y.Cheng Zhen Sun;Chen Liu;Steven Y.Cheng

作者机构：Department of Medical Genetics2Department of Pathology and Pathophysiology3Jiangsu Key Lab of Cancer BiomarkersPrevention and TreatmentCollaborative Innovation Center for Cancer Personalized MedicineNanjing Medical UniversityNanjingJiangsu 211166China. 

出 版 物：《The Journal of Biomedical Research》 (生物医学研究杂志（英文版）)

年 卷 期：2021年第35卷第1期

页      面：21-35,I0005-I0013页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by grants from the National Natural Science Foundation of China(No.81672748 and No.81871936) 

主　　题：colorectal cancer Gene Expression Omnibus biomarkers bioinformatics analysis 

摘      要：Colorectal cancer(CRC)is one of the most deadly cancers in the world with few reliable biomarkers that have been selected into clinical guidelines for prognosis of CRC *** this study,mRNA microarray datasets GSE113513,GSE21510,GSE44076,and GSE32323 were obtained from the Gene Expression Omnibus(GEO)and analyzed with bioinformatics to identify hub genes in CRC *** expressed genes(DEGs)were analyzed using the GEO2 R *** ontology(GO)and KEGG analyses were performed through the DAVID *** database and Cytoscape software were used to construct a protein-protein interaction(PPI)network and identify key modules and hub *** analyses of the DEGs were performed on GEPIA *** Connectivity Map database was used to screen potential drugs.A total of 865 DEGs were identified,including 374 upregulated and 491 downregulated *** DEGs were mainly associated with metabolic pathways,pathways in cancer,cell cycle and so *** PPI network was identified with 863 nodes and 5817 *** analysis revealed that HMMR,PAICS,ETFDH,and SCG2 were significantly associated with overall survival of CRC *** blebbistatin and sulconazole were identified as candidate *** conclusion,our study found four hub genes involved in CRC,which may provide novel potential biomarkers for CRC prognosis,and two potential candidate drugs for CRC.