Feasibility study for bone health assessment based on photoacoustic imaging method

作     者：Ting Feng Yunhao Zhu Yejing Xie Dean Ta Jie Yuan Qian Cheng 封婷;朱昀浩;谢业晶;他得安;袁杰;程茜

作者机构：School of Electronic and Optical EngineeringNanjing University of Science and TechnologyNanjing 210094China Institute of AcousticsSchool of Physics Science and EngineeringTongji UniversityShanghai 200092China School of Electronic Science and EngineeringNanjing UniversityNanjing 210094China Department of Electronic EngineeringFudan UniversityShanghai 200433China Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of EducationOrthopaedic Department of Tongji HospitalTongji University School of MedicineShanghai 200065China 

出 版 物：《Chinese Optics Letters》 (中国光学快报（英文版）)

年 卷 期：2020年第18卷第12期

页      面：49-53页

核心收录：

学科分类：1002[医学-临床医学] 08[工学] 080203[工学-机械设计及理论] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 0802[工学-机械工程] 10[医学] 

基　　金：the National Natural Science Foundation of China(Nos.11704188 and 11827808) the National Key Research and Development Project(No.2017YFC0111400) the Natural Science Foundation of Jiangsu Province(Nos.BK20170826 and BK20181256) the Postdoctoral Science Foundation of China(No.2019M651564) 

主　　题：photoacoustic imaging bone assessment osteoporosis bone health cliaracterization 

摘      要：This study investigated the feasibility of photoacoustic(PA) imaging of bone and characterization of bone features. By conducting the experiments on bovine femoral heads ex vivo, the light and ultrasonic penetration in bones was studied, together with the depth of PA imaging and measurement in bones. Then, the possibility of three-dimensional(3 D) PA imaging of bones by raster scanning of the focusing transducer was studied. The micro-computerized tomography images of the bovine ribs with and without ethylenediaminetetraacetic acid(EDTA) treatment indicated that the 3 D PA images could present the changes of bone microstructure resulting from the EDTA treatment. By using PA spectral analysis, the bone samples with and without the treatment of EDTA solution can be distinguished, and the microstructures can be characterized. This study was based on the bovine bone whose size is comparable to human bones, suggesting that PA technology can be used as a novel bone diagnostic technique.