Design and structural characterization of autoinhibition-compromised full-length Ran

作     者：Yuping Tan Yuqing Zhang Qiao Zhou Da Jia Qingxiang Sun Yuping Tan;Yuqing Zhang;Qiao Zhou;Da Jia;Qingxiang Sun

作者机构：Department of PathologyState Key Laboratory of Biotherapy and Cancer CentreWest China HospitalSichuan University and Collaborative Innovation Centre of BiotherapyChengdu 610041China Key Laboratory of Birth Defects and Related Diseases of Women and ChildrenDepartment of PaediatricsDivision of NeurologyWest China Second University HospitalSichuan UniversityChengdu 610041China 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2021年第6卷第3期

页      面：574-576页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(#80502629) 

主　　题：nude structural characterization 

摘      要：Dear Editor,The Ras-related nuclear protein Ran is a small GTPase that functions in nuclear transport,mitotic spindle formation,nuclear-envelope/nudear-pore complex assembly,and other diverse cytoplasmic activities.1,2 Unlike other Ras superfamily proteins,Ran contains a unique autoinhibitory C-terminal tail(C-tail)that accounts for an estimated tenfold lower affinity for GTP as compared with *** missense cancer mutations at the C-tail have been observed,but the biological significance is unknown.