A theory of mechanobiological sensation:strain amplification/attenuation of coated liquid inclusion with surface tension
作者机构：State Key Laboratory of Mechanics and Control of Mechanical StructuresNanjing University of Aeronautics and AstronauticsNanjing210016China Xi’an Modern Chemistry Research InstituteXi’an710065China State Key Laboratory for Strength and Vibration of Mechanical StructuresXi’an Jiaotong UniversityXi’an710049China Bioinspired Engineering&Biomechanics Center(BEBC)Xi’an Jiaotong UniversityXi’an710049China
出 版 物：《Acta Mechanica Sinica》 (力学学报（英文版）)
年 卷 期：2021年第37卷第1期
页 面：145-155,I0004页
核心收录：
学科分类：071011[理学-生物物理学] 0710[理学-生物学] 07[理学]
基 金：supported by the National Natural Science Foundation of China(Grants 12032010,11532009,and 11902155) the Natural Science Foundation of Jiangsu Province(Grant BK20190382) the foundation of“Jiangsu Provincial Key Laboratory of Bionic Functional Materials”,the Foundation for the Priority Academic Program Development of Jiangsu Higher Education Institutions
主 题：Surface tension Liquid inclusion Mechanobiological sensation Cancer cell
摘 要：Cells are compressible and can be regarded as a kind of coated liquid inclusion embedded in a three-dimensional elastic *** the presence of far-field loading,how the coating influences the mechanical response(e.g.,volume change)of the liquid inclusion remains elusive,especially when surface tension effects become significant at cell size *** developed a theoretical model to characterize the mechanical amplification or attenuation role of coating on spherical liquid inclusions,with surface tension and liquid compressibility accounted *** found that surface tension could increase the volumetric strain of the inclusion through decreasing its effective bulk *** further found that,when there is a monotonic stiffness variation(either decreasing or increasing)from matrix via coating to inclusion,the presence of coating amplified the volumetric strain compared with the case without coating;in the opposite,when there is a non-monotonic stiffness change from matrix via coating to inclusion,the volumetric strain is attenuated by the *** results are useful for understanding and exploring the mechanobiological sensation of certain types of cell,e.g.,osteocytes and cancer cells.
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