HIV prevalence in suspected Ebola cases during the 2014-2016 Ebola epidemic in Sierra Leone

作     者：William J.Liu Hai-Yang Hu Qiu-Dong Su Zhe Zhang Yang Liu Yu-Lan Sun Xian-Da Yang Da-Peng Sun Shao-Jian Cai Xiu-Xu Yang Idrissa Kamara Abdul Kamara Matt Lebby Brima Kargbo Patricia Ongpin Xiao-Ping Dong Yue-Long Shu Wen-Bo Xu Gui-Zhen Wu Michael Gboun George F.Gao Liu William J.;Hu Hai-Yang;Su Qiu-Dong;Zhang Zhe;Liu Yang;Sun Yu-Lan;Yang Xian-Da;Sun Da-Peng;Cai Shao-Jian;Yang Xiu-Xu;Kamara Idrissa;Kamara Abdul;Lebby Matt;Kargbo Brima;Ongpin Patricia;Dong Xiao-Ping;Shu Yue-Long;Xu Wen-Bo;Wu Gui-Zhen;Gboun Michael;Gao George F.

作者机构：NHC Key Laboratory of BiosafetyNational Institute for Viral Disease Control and PreventionChinese Center for Disease Control and Prevention(China CDC)Beijing 102206China Jiangsu Provincial Center for Disease control and PreventionNanjing 210009China Beijing Institute of BiotechnologyBeijing 100071China. Beijing Center for Disease Prevention and ControlBeijing 100013China Jilin Provincial Center for Disease control and PreventionChangchun 130021China Shandong Provincial Center for Disease control and PreventionJinan 250014China Fujian Provincial Center for Disease control and PreventionFuzhou 350001China The Ministry of Health and SanitationFreetownSierra Leone UNAIDSFreetownSierra Leone Chinese Center for Disease Control and PreventionBeijing 102206China CAS Key Laboratory of Pathogenic Microbiology and ImmunologyInstitute of MicrobiologyChinese Academy of Sciences(CAS)Beijing 100101China Sierra Leone-China Friendship Biological Safety LaboratoryFreetownSierra Leone 

出 版 物：《Infectious Diseases of Poverty》 (贫困所致传染病（英文）)

年 卷 期：2019年第8卷第2期

页      面：87-90页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：the National Mega-Project for Infectious Disease,Ministry of Science and Technology(Grant no.2016ZX10004222-003) National Key Project of Ebola Research,National Natural Science Foundation of China(NSFC,Grant no.81590763) NSFC projects for Dr.William J Liu(Grant no.81373141 and 81401312). 

主　　题：HIV HCV Ebola Prevalence Sierra Leone 

摘      要：Background:The 2014-2016 Ebola virus epidemic in West Africa was the largest outbreak of Ebola virus disease(EVD)in history.Clarifying the influence of other prevalent diseases such as human immunodeficiency virus infection and acquired immune deficiency syndrome(HIV/AIDS)will help improve treatment and supportive care of patients with EVD.Case presentation:We examined HIV and hepatitis C virus(HCV)antibody prevalence among suspected EVD cases from the Sierra Leone-China Friendship Biological Safety Laboratory during the epidemic in Sierra Leone.HIV and HCV antibodies were tested in 678 EVD-negative samples by enzyme-linked immunosorbent assay.A high HIV prevalence(17.6%)and low HCV prevalence(0.22%)were observed among the suspected cases.Notably,we found decreased HIV positive rates among the suspected cases over the course of the epidemic.This suggests a potentially beneficial effect of an improved public health system after assistance from the World Health Organization and other international aid organizations.Conclusions:This EVD epidemic had a considerable impact on the public health system and influenced the prevalence of HIV found among suspected cases in Sierra Leone,but also provided an opportunity to establish a better surveillance network for infectious diseases.