Structure-activity relationship of lysophosphatidylcholines in HL-60 human leukemia cells

作     者：Eun-hee LEE,Jee H JUNG,Dong-soon IM 

作者机构：Laboratories of Pharmacology and Marine Natural Product Laboratories of Pharmacology and Marine Natural Product Laboratories of Pharmacology and Marine Natural Product College of Pharmacy Pusan National University Busan 609-735 Korea College of Pharmacy Pusan National University Busan 609-735 Korea College of Pharmacy Pusan National University Busan 609-735 Korea 

出 版 物：《Acta Pharmacologica Sinica》 (中国药理学报(英文版))

年 卷 期：2004年第11期

页      面：137-140页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by the Korea Research Foundation Grant(KRF-2002-041-E00048) 

主　　题：lysophosphatidylcholines leukemia calcium signaling structure-activity relationship platelet activating factor 

摘      要：AIM: To explore the structure-activity relationship of lysophosphatidylcholine (LPC) and lysolipid molecules from a marine sponge and ladybirds. METHODS: We tested three synthetic LPCs and four natural lysolipids on Ca2+ mobilization in HL-60 human leukemia cells. RESULTS: We observed lysolipid-mediated Ca2+ mobilization. The activity was the same in both ester- and ether-linked lysolipids, and introduction of a double bond or methoxy group on the alkyl chain did not significantly modulate the activity. However, replacement of trimethylammonium moiety in the choline structure with ammonium moiety reduced the activity. Furthermore, change of the alkyl chain length influenced the Ca2+ response. CONCLUSION: LPC-induced Ca2+ mobilization might be dependent on the length of alkyl chain and the presence of choline moiety in HL-60 leukemia cells.