Drug-induced cardiomyopathy:Characterization of a rat model by[^18 F]FDG/PET and[^99m Tc]MIBI/SPECT

作     者：Hailey Houson Andria Hedrick Vibhudutta Awasthi Hailey Houson;Andria Hedrick;Vibhudutta Awasthi

作者机构：Research Imaging FacilityDepartment of Pharmaceutical SciencesCollege of PharmacyUniversity of Oklahoma Health Science CenterOklahoma CityOKUSA HexakitInc.EdmondOKUSA 

出 版 物：《Animal Models and Experimental Medicine》 (动物模型与实验医学（英文）)

年 卷 期：2020年第3卷第4期

页      面：295-303页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：National Heart,Lung,and Blood Institute,Grant/Award Number:R41HL140919-01 Sandra K.and David L.Gilliland Chair in Nuclear Pharmacy 

主　　题：[^18 F]-fluorodeoxyglucose [^99m Tc]-sestamibi cardiomyopathy imaging myocardial infarction positron emission tomography 

摘      要：Background:Drug-induced cardiomyopathy is a significant medical *** diagnosis of myocardial injury is based on initial electrocardiogram,levels of circulating biomarkers,and perfusion imaging with single photon emission computed tomography(SPECT).Positron emission tomography(PET)is an alternative imaging modality that provides better resolution and sensitivity than SPECT,improves diagnostic accuracy,and allows therapeutic *** objective of this study was to assess the detection of drug-induced cardiomyopathy by PET using 2-deoxy-2-[^18F]fluoro-D-glucose(FDG)and compare it with the conventional SPECT technique with[^99m Tc]-Sestamibi(MIBI).Methods:Cardiomyopathy was induced in Sprague Dawley rats using high-dose ***[^18F]FDG/PET and[^99m Tc]MIBI/SPECT were performed before and after isoproterenol administration.[^18F]FDG(0.1 mCi,200-400μL)and[^99m Tc]MIBI(2 mCi,200-600μL)were administered via the tail vein and imaging was performed 1 hour ***-induced injury was confirmed by the plasma level of cardiac troponin and triphenyltetrazolium chloride(TTC)***:Isoproterenol administration resulted in an increase in circulating cardiac troponin I and showed histologic damage in the ***,preisoproterenol and postisoproterenol images showed alterations in cardiac accumulation of[^18F]FDG,but not of[^99m Tc]*** analysis revealed that myocardial uptake of[^18F]FDG reduced by 60%after isoproterenol treatment,whereas that of[^99m Tc]MIBI decreased by 45%.Conclusion:We conclude that[^18F]FDG is a more sensitive radiotracer than[^99m Tc]MIBI for imaging of drug-induced *** theorize that isoproterenolinduced cardiomyopathy impacts cellular metabolism more than perfusion,which results in more substantial changes in[^18F]FDG uptake than in[^99m Tc]MIBI accumulation in cardiac tissue.