缺血/再灌注损伤时丝裂原活化蛋白激酶信号转导通路的变化
Changes of mitogen-activated protein kinases signal transduction pathway in ischemia/reperfusion injury作者机构：北京医科大学第一医院肾内科暨肾脏病研究所北京100034
出 版 物：《中国病理生理杂志》 (Chinese Journal of Pathophysiology)
年 卷 期：2000年第16卷第12期
页 面：1335-1337页
核心收录：
学科分类：1001[医学-基础医学(可授医学、理学学位)] 100104[医学-病理学与病理生理学] 10[医学]
基 金：教育部博士学科点基金! (No .95 0 10 2 9)
摘 要：Mitogen-activated protein kinases (MAPKs), including extracellular signal-regulated kinases (ERKs), c-Jun NH2-terminal kinases (JNKs) and p38 MAPK, play an important role in transducting environmental stimuli to the transcriptional machinery in the nucleus in mammalian cells by virtue of their ability to phosphorylate and regulate the activity of various transcription factors. It was recently found that the changes in activity of MAPKs occurred during ischemia/reperfusion, but the biological significance of the changes was still controversial.
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