Bioinformatics analysis of metastasis-related proteins in hepatocellular carcinoma

作     者：Pei-Ming Song Yang Zhang Yu-Fei He Hui-Min Bao Jian-Hua Luo Yin-Kun Liu Peng-Yuan Yang Xian Chen 

作者机构：School of Life Sciences and Biotechnology Shanghai Jiao Tong University Shanghai 200030 China Institute of Biomedical Science Fudan University Shanghai 200320 China Department of Biochemistry and Biophysics University of North Carolina at Chapel Hill Chapel Hill North Carolina 27599 United States 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2008年第14卷第38期

页      面：5816-5822页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：National Basic Research Priorities Program No. 2001CB510202 National Science and Technology Key Project No. 2002BAC11A11 and 2004BA711A19 National Natural Science Foundation of China No. 20328508 National High Technology Research Developing Program No. 02BAC11A11 Shanghai Science and Technology Development Program No. 03DZ14024 

主　　题：Hepatocellular carcinoma Metastasis Bioinformatics Protein-protein interaction Kyoto encyclopedia of genes and genomes 

摘      要：AIM: To analyze the metastasis-related proteins in hepatocellular carcinoma (HCC) and discover the biomarker candidates for diagnosis and therapeutic intervention of HCC metastasis with bioinformatics tools. METHODS: Metastasis-related proteins were determined by stable isotope labeling and MS analysis and analyzed with bioinformatics resources, including Phobius, Kyoto encyclopedia of genes and genomes (KEGG), online mendelian inheritance in man (OMIM) and human protein reference database (HPRD). RESULTS: All the metastasis-related proteins were linked to 83 pathways in KEGG, including MAPK and p53 signal pathways. Protein-protein interaction network showed that all the metastasis-related proteins were categorized into 19 function groups, including cell cycle, apoptosis and signal transduction. OMIM analysis linked these proteins to 186 OMIM entries. CONCLUSION: Metastasis-related proteins provide HCC cells with biological advantages in cell proliferation,migration and angiogenesis, and facilitate metastasis of HCC cells. The bird s eye view can reveal a global characteristic of metastasis-related proteins and many differentially expressed proteins can be identified as candidates for diagnosis and treatment of HCC.