Effects of creative expression program on the event-related potential and task reaction time of elderly with mild cognitive impairment

作     者：Junyu Zhao Hong Li Rong Lin Minzhi Xie Yinzhou Wang Huiying Chen 赵珺瑜;李红;林榕;谢忞之;汪银洲;陈惠英

作者机构：School of NursingFujian Medical UniversityFuzhouChina Department of NursingFujian Provincial HospitalFuzhouChina Department of NeurologyFujian Provincial HospitalFuzhouChina Center of Patients Admission and Discharge ServiceFujian Provincial HospitalFuzhouChina 

出 版 物：《International Journal of Nursing Sciences》 (国际护理科学（英文）)

年 卷 期：2021年第8卷第1期

页      面：38-42,I0003页

核心收录：

学科分类：1011[医学-护理学（可授医学、理学学位）] 10[医学] 

基　　金：supported by the Youth research project of Fujian Provincial Health Commission(No.2018-1-75) Joint Fund of Fujian Province Scientific and Technological Department(No.2018Y9102) Soft Science Project of Fujian Science and Technology Department(No.2019R0055) National Science Foundation of China(No.81571379) 

主　　题：Aged Cognitive therapy Event-related potentials Mild cognitive impairment Reaction time 

摘      要：Objectives:This study aimed to evaluate the effects of a 16-week creative expression intervention program(CrExp)on the event-related potential(ERP)and task reaction time in older individuals with mild cognitive impairment(MCI).Methods:This study is a randomized controlled clinical trial conducted in the Memory Center of Fujian Provincial ***-six MCI patients were randomly distributed into two *** group underwent a 16-week creative expression program(CrExp,n=18)and the other performed as a control group(CG,n=18)by general social *** amplitude and latency of ERP-P300 from the central(Cz),parietal(Pz),frontal(Fz)cortices and task reaction time(RT)were assessed at baseline,postinterventi on,and 24-week ***:The CrExp group showed greater differences than CG of P300 latency in Cz(F=4.37,P=0.015),Pz(F=2.78,P=0.009),Fz(F=6.45,P=0.031)brain area after 16 weeks of intervention and in Fz(F=3.23,P=0.028),Cz(F=3.79,P=0.024),and Pz(F=5.60,P=0.036)at 24 weeks ***,we analyzed the task reaction time between two groups and found that a shorten reaction time at postintervention(F=4.47,P=0.011)and 24 weeks follow-up(F=3.12,P=0.007)in the CrExp ***,there was no difference in P300 amplitude in either brain area between the two ***:The electrophysiological results of the creative expression cognitive therapy group were more obvious than those of the general cognitive therapy group,and the latency and task reaction time may be considered as supported parameters in diagnosing the effects during non-drug therapy intervention in clinical practice.