Pathogenesis of NASH and Promising Natural Products

作     者：LENG Ying-Rong ZHANG Mei-Hui LUO Jian-Guang ZHANG Hao LENG Ying-Rong;ZHANG Mei-Hui;LUO Jian-Guang;ZHANG Hao

作者机构：State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Bioactive Natural Product ResearchSchool of Traditional Chinese PharmacyChina Pharmaceutical UniversityNanjing 210009China 

出 版 物：《Chinese Journal of Natural Medicines》 (中国天然药物（英文版）)

年 卷 期：2021年第19卷第1期

页      面：12-27页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(No.81872889) the Drug Innovation Major Project(Nos.2018ZX09711-001-007 and 2018ZX09735002-003) 

主　　题：NASH Natural medicine Animal model Target Pathogenesis 

摘      要：Nonalcoholic steatohepatitis(NASH)is a common clinical condition that can lead to advanced liver *** mechanism of the diaease progression,which is lacking effective therapy,remains ***,there is a need to understand the pathogenic mechanisms responsible for disease development and progression in order to develop innovative *** accomplish this goal,experimental animal models that recapitulate the human disease are ***,an increasing number of studies have focused on natural constituents from medicinal plants which have been emerged as a new hope for *** review summarized the pathogenesis of NASH,animal models commonly used,and the promising targets for *** also reviewed the natural constituents as potential NASH therapeutic agents.