DNA alkylation lesion repair: outcomes and implications in cancer chemotherapy

作     者：Yihan PENG Huadong PEI Yihan PENG;Huadong PEI

作者机构：Department of Biochemistry and Molecular Medicinethe George Washington University School of Medicine and Health SciencesWashingtonDC 20037USA GW Cancer Centerthe George Washington University School of Medicine and Health SciencesWashingtonDC 20052USA 

出 版 物：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 (浙江大学学报（英文版）B辑（生物医学与生物技术）)

年 卷 期：2021年第22卷第1期

页      面：47-62页

核心收录：

学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 0905[农学-畜牧学] 0906[农学-兽医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Alkylation repair Base excision repair Methyl-guanine methyltransferase(MGMT) AlkB homolog(ALKBH) 

摘      要：Alkylated DNA lesions, induced by both exogenous chemical agents and endogenous metabolites, represent a major form of DNA damage in cells. The repair of alkylation damage is critical in all cells because such damage is cytotoxic and potentially mutagenic. Alkylation chemotherapy is a major therapeutic modality for many tumors, underscoring the importance of the repair pathways in cancer cells. Several different pathways exist for alkylation repair, including base excision and nucleotide excision repair, direct reversal by methyl-guanine methyltransferase(MGMT), and dealkylation by the AlkB homolog(ALKBH) protein family. However, maintaining a proper balance between these pathways is crucial for the favorable response of an organism to alkylating agents. Here, we summarize the progress in the field of DNA alkylation lesion repair and describe the implications for cancer chemotherapy.