Epstein-Barr virus-associated monomorphic post-transplant lymphoproliferative disorder after pediatric kidney transplantation: A case report

作     者：Zhen Wang Yang Xu Jie Zhao Ying-Xin Fu 

作者机构：Department of Kidney TransplantationTianjin First Central HospitalTianjin 300192China 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2021年第9卷第2期

页      面：469-475页

核心收录：

学科分类：1002[医学-临床医学] 100202[医学-儿科学] 10[医学] 

主　　题：Post-transplant lymphoproliferative disorder Epstein-Barr virus Kidney transplantation Case report Biopsy Calcineurin inhibitors 

摘      要：BACKGROUND Post-transplant lymphoproliferative disease(PTLD)is the most common malignant tumor that occurs after kidney transplantation in children,and is associated with Epstein-Barr virus(EBV).CASE SUMMARY We report a case of PTLD that occurred in a 17-year-old female patient at 5 mo *** first symptom was abdominal pain accompanied by fever,nausea,and ***-associated monomorphic PTLD with multiple abdominal nodules was diagnosed by pathology,clinical manifestations,imaging results,and the presence of *** successful treatment with rituximab,the abdominal nodules in the spleen and liver *** Early pathological biopsy to confirm the diagnosis is critical to treatment and *** immunosuppression and rituximab therapy are effective methods for treating PTLD,but need to be initiated as early as possible.