Cerebral regional and network characteristics in asthma patients: a resting-state fMRI study
作者机构：Huaxi MR Research Center(HMRRC)Department of RadiologyWest China Hospital of Sichuan UniversityChengdu 610041China Department of AnesthesiologyWest China Hospital of Sichuan UniversityChengdu 610041China Department of Respiratory MedicineWest China HospitalSichuan UniversityChengdu 610041China Department of RadiologySichuan Cancer Hospital&InstituteSichuan Cancer CenterSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610041China Department of Geriatric PsychiatryThe Fourth People’s Hospital of ChengduChengdu 610036China
出 版 物：《Frontiers of Medicine》 (医学前沿（英文版）)
年 卷 期：2020年第14卷第6期
页 面：792-801页
核心收录：
基 金：This study was supported by the National Natural Science Foundation of China(Nos.81671664 and 81621003) National Program for Support of Top-notch Young Professionals(No.W02070140) Fundamental Research Funds for the Central Universities(No.2018SCUH0011) Science and Technology Project of the Health Commission of Sichuan Province(No.18ZD035) Sichuan Science and Technology Program(No.2019YJ0155) 1-3-5 Project for Disciplines of Excellence,West China Hospital,Sichuan University(Nos.ZYYC08001 and ZYJC18020).
主 题：asthma brain regional activation functional connectivity resting-state fMRI
摘 要：Asthma is a serious health problem that involves not only the respiratory system but also the central nervous system.Previous studies identified either regional or network alterations in patients with asthma,but inconsistent results were obtained.A key question remains unclear:are the regional and neural network deficits related or are they two independent characteristics in asthma?Answering this question is the aim of this study.By collecting resting-state functional magnetic resonance imaging from 39 patients with asthma and 40 matched health controls,brain functional measures including regional activity(amplitude of low-frequency fluctuations)and neural network function(degree centrality(DC)and functional connectivity)were calculated to systematically characterize the functional alterations.Patients exhibited regional abnormities in the left angular gyrus,right precuneus,and inferior temporal gyrus within the default mode network.Network abnormalities involved both the sensorimotor network and visual network with key regions including the superior frontal gyrus and occipital lobes.Altered DC in the lingual gyrus was correlated with the degree of airway obstruction.This study elucidated different patterns of regional and network changes,thereby suggesting that the two parameters reflect different brain characteristics of asthma.These findings provide evidence for further understanding the potential cerebral alterations in the pathophysiology of asthma.
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