Enantioselective Synthesis of Tetrahydroquinolines via One-Pot Cascade Biomimetic Reduction

作     者：Zi-Biao Zhao Xiang Li Mu-Wang Chen Bo Wu Yong-Gui Zhou Zi-Biao Zhao;Xiang Li;Mu-Wang Chen;Bo Wu;Yong-Gui Zhou

作者机构：State Key Laboratory of CatalysisDalian Institute of Chemical PhysicsChinese Academy of SciencesDalianLiaoning 116023China State Key Laboratory of Organometallic ChemistryShanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China 

出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)

年 卷 期：2020年第38卷第12期

页      面：1691-1695页

核心收录：

学科分类：07[理学] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：Financial support from the National Natural Science Foundation of China(Nos.21532006,21690074) Chinese Academy of Sciences(Nos.XDB17020300,QYZDJ-SSW-SLHO35,DICP 1202002)is acknowledged. 

主　　题：reduction. catalyzed quinoline 

摘      要：of main observation and conclusion A novel and efficient protocol for the synthesis of chiral tetrahydroquinoline derivatives with excellent enantioselectivities and high yields has been developed through one-pot cascade biomimetic reduction.The detailed reaction pathway includes the acid-catalyzed and ruthenium-catalyzed formation of aromatic quinoline intermediates and biomimetic asymmetric reduction.