Near-Infrared Fluorescent Nanoprobe for Detecting Hydrogen Peroxide in Inflammation and Ischemic Kidney Injury

作     者：Lingfeng Xu Lihe Sun Fang Zeng Shuizhu Wu Lingfeng Xu;Lihe Sun;Fang Zeng;Shuizhu Wu

作者机构：State Key Laboratory of Luminescent Materials&DevicesGuangdong Provincial Key Laboratory of Luminescence from Molecular AggregatesCollege of Materials Science&EngineeringSouth China University of TechnologyGuangzhouGuangdong 510640China 

出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)

年 卷 期：2020年第38卷第11期

页      面：1304-1310页

核心收录：

学科分类：1002[医学-临床医学] 07[理学] 070302[理学-分析化学] 0703[理学-化学] 10[医学] 

基　　金：This work was supported by NSFC(51673066,21875069 and 21574044) the Natural Science Foundation of Guangdong Province(2016A030312002) the Fund of Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates(2019B030301003). 

主　　题：inflammation Kidney acute 

摘      要：of main observation and conclusion In-situ overexpressed hydrogen peroxide could serve as a biomarker for inflammation and ischemic kidney injury.Herein,a nanoprobe was developed for assay of hydrogen peroxide.The nanoprobe(TA-TPABQ)was formed via the boronate ester groups between the hydrophilic tannic acid and the boric-acid-containing compound(TPABQ)as well as the hydrophobic interactions.The probe with good photostability shows good sensitivity and selectivity towards H2O2-The probe was adopted for identifying endogenous and exogenous H2O2 in living cells.Moreover,the probe was utilized for in vivo imaging experiments in acute abdomina and ankle inflammation mouse models as well as acute renal ischemia mouse model.