The molecular implications of a caspase-2-mediated site-specific tau cleavage in tauopathies

作     者：Peng Liu Karen H.Ashe Peng Liu;Karen H.Ashe

作者机构：Department of NeurologyUniversity of MinnesotaMinneapolisMNUSA Department of NeuroscienceUniversity of MinnesotaMinneapolisMNUSA N.Bud Grossman Center for Memory Research and CareUniversity of MinnesotaMinneapolisMNUSA Geriatric ResearchEducationand Clinical CentersVeterans Affairs Medical CenterMinneapolisMNUSA 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2021年第16卷第9期

页      面：1774-1775页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100204[医学-神经病学] 10[医学] 

基　　金：supported by National Institutes of Health R01 AG060766 and R01 AG062199(to KHA)。 

主　　题：tau structural cleavage 

摘      要：A major focus of current experimental therapies for neurodegenerative diseases is on modulating post-translational modifications(PTMs)of the microtubule-associated protein tau.Tau is a highly soluble,neuronal protein that is comprised of four domains–the N-terminal projection domain,the proline-rich region,the microtubule-binding domain,and the C-terminal tail.As a scaffold protein,tau dynamically interacts with numerous structural and functional biomolecules,such as cytoskeleton and motor proteins,chaperones,enzymes,DNA,RNA,and lipids.Over a dozen types of PTMs,combined with alternative splicing,confer upon tau its enormous structural heterogeneity,which subserves its many(patho-)physiological functions.