Voltammetric quantification of anti-hepatitis drug Adefovir in biological matrix and pharmaceutical formulation

作     者：Rajeev Jain Ramkishor Sharma 

作者机构：School of Studies in ChemistryJiwaji University 

出 版 物：《Journal of Pharmaceutical Analysis》 (药物分析学报（英文版）)

年 卷 期：2012年第2卷第2期

页      面：98-104页

学科分类：1007[医学-药学(可授医学、理学学位)] 10[医学] 

主　　题：Voltammetry Adefovir Solid-phase extraction Protein-precipitation Human plasma Pharmaceutical formulation 

摘      要：Electrochemical reduction behavior of Adefovir was studied using Hanging Mercury Drop Electrode (HMDE) in Britton-Robinson (BR) buffer *** study showed one well-defined reduction peak in the potential range -1.2 to -1.4 V (***/AgCl) due to reduction of C=N bond of the imidazole ***-phase extraction and protein-precipitation techniques were employed for extraction of Adefovir from human *** proposed method allows quantification of Adefovir in human plasma over the concentration range 0.50-5.00 μg/mL with the detection limit 0.17 μg/mL,whereas in pharmaceutical formulation 0.25-2.25 μg/mL with the detection limit 0.08 μg/mL.