Application of a real-ambient fine particulate matter exposure system on different animal models

作     者：Yuanyuan Song Lifang Zhao Zenghua Qi Yanhao Zhang Guodong Cao Ruijin Li Lin Zhu Zhu Yang Chuan Dong Zongwei Cai Yuanyuan Song;Lifang Zhao;Zenghua Qi;Yanhao Zhang;Guodong Cao;Ruijin Li;Lin Zhu;Zhu Yang;Chuan Dong;Zongwei Cai

作者机构：State Key Laboratory of Environmental and Biological AnalysisDepartment of ChemistryHong Kong Baptist UniversityHong Kong SARChina Institute of Environmental ScienceShanxi UniversityTaiyuan 030006China School of Environmental Science and EngineeringGuangdong University of TechnologyGuangzhou 510006China 

出 版 物：《Journal of Environmental Sciences》 (环境科学学报（英文版）)

年 卷 期：2021年第33卷第7期

页      面：64-70页

核心收录：

学科分类：083002[工学-环境工程] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 07[理学] 08[工学] 070602[理学-大气物理学与大气环境] 09[农学] 0903[农学-农业资源与环境] 0706[理学-大气科学] 0713[理学-生态学] 

基　　金：supported by the National Natural Science Foundation of China(Nos.91843301,91543202 and 21806025) collaborative research fund from the Research Grants Council of Hong Kong(No.C2014-14E) 

主　　题：Real-ambient PM_(2.5)exposure system Adverse effects Sirt3 KO Aged mice 

摘      要：Simulation of fine particulate matter(PM_(2.5))exposure is essential for evaluating adverse health *** this work,an ambient exposure system that mimicked real atmospheric conditions was installed in Taiyuan,China to study impacts of chronic PM_(2.5) exposure on adult and aged mice as well as Sirtuin3 knockout(Sirt3 KO)mice and wild-type(WT)*** real-ambient exposure system eliminated the possible artificial effects caused from exposure experiments and maintained the physiochemical characteristics of PM_(2.5).The case studies indicated that aged mice exhibited apparent heart dysfunction involving in-creased heart rate and decreased blood pressure after 17-week of real-ambient PM_(2.5) ***,15-week of real-ambient PM_(2.5) exposure decreased the heart rate and amounts of associated catecholamines to induce heart failure in Sirt3 KO ***,the increased pro-inflammatory cytokines and decreased platelet related indices suggested that inflammation *** changes of biomarkers detected by targeted metabolomics confirmed metabolic disorder in WT and Sirt3 KO mice after exposed to real-ambient PM_(2.5).These results indicated that the real-ambient PM_(2.5) exposure system could evaluate the risks of certain diseases associated with air pollution and have great potential for support-ing the investigations of PM_(2.5) effects on other types of rodent models.