Versatile iron-vitamin K_(3) derivative-based nanoscale coordination polymer augments tumor ferroptotic therapy

作     者：Zhicheng Zhang Yawen Ding Jinbiao Li Li Wang Xiaoyan Xin Jing Yan Jinhui Wu Ahu Yuan Yiqiao Hu Zhicheng Zhang;Yawen Ding;Jinbiao Li;Li Wang;Xiaoyan Xin;Jing Yan;Jinhui Wu;Ahu Yuan;Yiqiao Hu

作者机构：State Key Laboratory of Pharmaceutical BiotechnologyMedical School/School of Life SciencesNanjing UniversityNanjing 210093China Department of RadiologyNanjing Drum Tower HospitalMedical School of Nanjing UniversityNanjing 210008China The Comprehensive Cancer Centre of Nanjing Drum Tower HospitalMedical School/Clinical Cancer InstituteNanjing UniversityNanjing 210093China 

出 版 物：《Nano Research》 (纳米研究（英文版）)

年 卷 期：2021年第14卷第7期

页      面：2398-2409页

核心收录：

学科分类：0808[工学-电气工程] 1002[医学-临床医学] 0809[工学-电子科学与技术（可授工学、理学学位）] 0805[工学-材料科学与工程（可授工学、理学学位）] 100214[医学-肿瘤学] 0702[理学-物理学] 10[医学] 

基　　金：This article was supported by The National Key Research and Development Program of China(No.2017YFA0205400) Natural Science Foundation of China(NSFC)(Nos.81603043,81872811,and 31872755) This project was also supported by the Central Fundamental Research Funds for the Central Universities 

主　　题：ferroptosis vitamin K_(3)derivative nanoscale coordination polymer glutathione peroxidase attenuation iron pool increase hydrogen peroxide generation 

摘      要：Ferroptosis is a newly form of regulated cell death,which has attracted great attention for tumor ***,we prepared nanoscale coordination polymer Fe-NQA particles to deliver iron and NQA(vitamin K3 derivative)into tumor cells,which synergistically promoted ferroptotic therapy for inhibiting tumor growth,preventing metastasis,and overcoming radioresistance.