Oxidative stress and mitochondrial transfer:A new dimension towards ocular diseases

作     者：Mohana Devi Subramaniam Mahalaxmi Iyer Aswathy P.Nair Dhivya Venkatesan Sinnakaruppan Mathavan Nimmisha Eruppakotte Soumya Kizhakkillach Manoj kumar Chandran Ayan Roy Abilash Valsala Gopalakrishnan Balachandar Vellingiri 

作者机构：SN ONGC Department of Genetics and Molecular BiologyVision Research FoundationChennai 600006Tamil NaduIndia Department of ZoologyAvinashilingam Institute for Home Science and Higher Education for WomenCoimbatore 641043Tamil NaduIndia Human Molecular Cytogenetics and Stem Cell LaboratoryDepartment of Human Genetics and Molecular BiologyBharathiar UniversityCoimbatore 641046Tamil NaduIndia Department of BiotechnologyLovely Professional UniversityPunjab 144411India Department of Biomedical SciencesSchool of Bio Sciences and Technology(SBST)Vellore Institute of Technology(VIT)Vellore 600127India 

出 版 物：《Genes & Diseases》 (基因与疾病（英文）)

年 卷 期：2022年第9卷第3期

页      面：610-637页

核心收录：

学科分类：1002[医学-临床医学] 100212[医学-眼科学] 10[医学] 

基　　金：The authors would like to thank the Science and Engi・neering Research Board(ECR/2018/000718) Indian Council of Medical Research(File No.2018-2786/CMB/Adhoc-BMS)and Countil for Scie ntific and In dustrial Research((Ref No.:27(0353)/19/EMR-ll),Government of India,New Delhi for providing necessary funding to complete this review article successfully 

主　　题：Mitochondrial transfer Oxidative stress Retinal pigment epithelium(RPE) RPE Degeneration Stem cell treatment 

摘      要：Ocular cells like,retinal pigment epithelium(RPE)is a highly specialized pigmented monolayer of post-mitotic cells,which is located in the posterior segment of the eye between neuro sensory retina and vascular *** functions as a selective barrier and nourishes retinal visual *** a result of high-level oxygen consumption of retinal cells,RPE cells are vulnerable to chronic oxidative stress and an increased level of reactive oxygen species(ROS)generated from *** oxidative stress and ROS generation in retinal cells lead to RPE *** sources including mtDNA damage could be an important factor of oxidative stress in *** therapy and mitochondrial transfer studies are emerging fields in ocular disease *** retinal degenerative diseases stem cell-based transplantation methods are developed from basic research to preclinical and clinical *** research contributions of gene and cell therapy would be a new strategy to prevent,treat and cure various ocular *** review focuses on the effect of oxidative stress in ocular cell degeneration and recent translational researches on retinal degenerative diseases to cure blindness.