Ameliorating Effects of Thyroxine and Atropine in Phosphamidon Intoxicated Chick Embryos

作     者：CHATTALI GHOSH AND J.N.MEDDA (Department of Zoology, Burdwan University, Burdwan 713104,West Bengal, INDIA)J.N.MEDDA (To whom all corespondences should be addressed.E-mail:zoojnm@burdwan.ernet.in.) CHATTALI GHOSH AND J.N.MEDDA (Department of Zoology, Burdwan University, Burdwan 713104,West Bengal, INDIA)J.N.MEDDA (To whom all corespondences should be addressed.E-mail:zoojnm@burdwan.ernet.in.)

作者机构：Burdwan University 印度 

出 版 物：《Biomedical and Environmental Sciences》 (生物医学与环境科学（英文版）)

年 卷 期：1999年第12卷第1期

页      面：34-42页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 100602[医学-中西医结合临床] 10[医学] 

主　　题：Animals Atropine Body Weight Central Nervous System Chick Embryo Cholinesterase Inhibitors Cholinesterases Dose-Response Relationship, Drug Insecticides Kidney Liver Phosphamidon Thyroxine 

摘      要：The effects of thyroxine and atropine in ameliorating phosphamidon intoxication in chick embryos was studied. Treatment of phosphamidon significantly enhanced the moriality and abnormalityrates, decreased the average body weights, and cholinesterase activity in chick embryos. When thyroxine was administered to the phosphamidon intoxicated embryos, the above parameters changedsignificantly, indicating an ameliorating effect of thyroxine against phosphamidon intoxication in chick embryos. The combined thyroxine and atropine therapy did not further improve the ameliorating effect. Since in many respects chick embryo development parallels that of mammalian embryos,a short-term use of thyroxine as a protective agent against organophosphate toxicity might be useful