Characteristics of optic disc parameters and its association in normal Chinese population： the Handan Eye Study

作     者：Zhang Qing Li Sizhen Liang Yuanbo Wang Fenghua Chen Weiwei Wang Ningli 

作者机构：Beijing Institute of Ophthalmology Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical University Beijing Ophthalmology and Visual Science Key Laboratory Beijing 100730 China Nanjing Aier Eye Hospital Nanjing Jiangsu 210006 China School of Ophthalmology & Optometry Wenzhou Medical College Wenzhou Zhejiang 325000 China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2014年第127卷第9期

页      面：1702-1709页

核心收录：

学科分类：1002[医学-临床医学] 100212[医学-眼科学] 10[医学] 

基　　金：supported by a grant from the Special Research Fund of Ministry of Health of the People’s Republic of China 

主　　题：optic disc primary open-angle glaucoma myopia 

摘      要：Background Assessment of the optic disc and retinal nerve fiber layer （RNFL） is essential for the diagnosis and monitoring of *** of normal optic disc topography provides a benchmark for evaluating glaucomatous pathologic changes,especially in its early *** purpose of this study was to evaluate the characteristics and correlation factors of the optic disc parameters using the Heidelberg Retina Tomograph Ⅱ （HRT Ⅱ） in a large sample of normal eyes of adult Chinese *** Disc data were obtained from 6 830 subjects aged 30 years from the Handan Eye *** participants underwent comprehensive eye examinations and physical *** associations of gender,age,body mass index,blood pressure,waist-to-hip ratio; refractive error,intraocular pressure,axial length,and disc area were assessed using simple and multiple regression *** correlation between HRT Ⅱ parameters was *** Of the 7 557 eligible subjects,6 830 took part in the study （90.4％ response rate） and 2 633 normal eyes with good-quality HRT Ⅱ images were *** mean disc area was 2.28 mm2 （standard deviation （SD） 0.43） and mean neural rim area was 1.80 mm2 （SD 0.29）.In multiple regression analysis,optic disc area significantly correlated with age,gender,and axial length （P 0.001）.All optic disc parameters showed a significant correlation with disc area （0.054 r 0.736,P 0.01）.The association between mean RNFL thickness and rim area is statistically significant but not strong （regression linear equation：rim area =1.42 × mean RNFL thickness ＋ 1.32 mm2,P 0.001; R2=0.070）.The global RNFL cross-sectional area was significantly associated with global rim area （regression linear equation：rim area =1.14× RNFL cross-sectional area ＋ 0.44 mm2,P 0.001; R2 =0.271）.Conclusions The optic disc area in rural Chinese population is larger than reported in white and Japanese populations,similar to that of Indian population and urban Chinese *** opt