Mutations of p53 gene exons 4-8 in human esophageal cancer
Mutations of p53 gene exons 4-8 in human esophageal cancer作者机构：DepartmentofOncologyChina-JapanFriendshipHospitalBeijing100029China InstituteofMedicalPhysicsandEngineeringTsinghuaUniversityBeijing100084China
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2005年第11卷第19期
页 面：2998-3001页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：Supported by Ministry of Science and Technology of the People´ s Republic of China grants No. 2003CA04200 and 2004CB720301 National Natural Science Foundation of China grant No.10490195 and 30271465 Beijing Municipal Science & Technology Commission grant No. H030230160130 in part by a grant from Tsinghua University YUYUAN foundation
摘 要：AIM: To characterize the tumor suppressor gene p53 mutations in exon 4, esophageal cancer and adjacent noncancerous ***: We performed p53 (exons 4-8) gene mutation analysis on 24 surgically resected human esophageal cancer specimens by PCR, single-strand conformation polymorphism, and DNA sequencing. RESULTS: p53 gene mutations were detected in 9 of 22 (40.9%) esophageal cancer specimens and 10 of 17 (58.8%) adjacent non-cancerous tissues. Eight of sixteen (50.0%) point mutations detected were G-A transitions and 9 of 18 (50.0%) p53 gene mutations occurred in exon 4 in esophageal cancer specimens. Only 1 of 11 mutations detected was G-A transition and 4 of 11 (36.4%) p53 gene mutations occurred in exon 4 in adjacent non-cancerous ***: Mutation of p53 gene in exon 4 may play an important role in development of esophageal cancer. The observation of p53 gene mutation in adjacent noncancerous tissues suggests that p53 gene mutation may be an early event in esophageal carcinogenesis. Some clinical factors, including age, sex, pre-operation therapy and location of tumors, do not influence p53 gene mutation rates.
维普期刊数据库