A combined statistical model for multiple motifs search

作     者：高丽锋 刘鑫 官山 

作者机构：Chinese Academy of Agriculture Science Institute of Theoretical Physics Physics Science and Technology Department Yangzhou University 

出 版 物：《Chinese Physics B》 (中国物理B（英文版）)

年 卷 期：2008年第17卷第12期

页      面：4396-4400页

核心收录：

学科分类：0809[工学-电子科学与技术（可授工学、理学学位）] 08[工学] 

基　　金：Project supported by the National Natural Science Foundation of China (Grant No 70671089) the Key Important Project(No 10635040) 

主　　题：transcription factor binding sites motif position weight matrix 

摘      要：Transcription factor binding sites （TFBS） play key roles in genebior 6.8 wavelet expression and regulation. They are short sequence segments with definite structure and can be recognized by the corresponding transcription factors correctly. From the viewpoint of statistics, the candidates of TFBS should be quite different from the segments that are randomly combined together by nucleotide. This paper proposes a combined statistical model for finding over- represented short sequence segments in different kinds of data set. While the over-represented short sequence segment is described by position weight matrix, the nucleotide distribution at most sites of the segment should be far from the background nucleotide distribution. The central idea of this approach is to search for such kind of signals. This algorithm is tested on 3 data sets, including binding sites data set of cyclic AMP receptor protein in ***, PlantProm DB which is a non-redundant collection of proximal promoter sequences from different species, collection of the intergenic sequences of the whole genome of ***. Even though the complexity of these three data sets is quite different, the results show that this model is rather general and sensible.