低风险角膜移植术后影响角膜新生血管形成的手术相关因素
Surgery-related factors influencing corneal neovascularization after low-risk keratoplasty作者机构：Department of Ophthalmology Friedrich-Alexa-nder University Erlangen-Nürnberg Schwabachanlage 6 D-91054 ErlangenGermany Dr.
出 版 物：《世界核心医学期刊文摘(眼科学分册)》 (Digest of the World Core Medical Journals)
年 卷 期：2006年第5期
页 面：7-8页
学科分类：1002[医学-临床医学] 100212[医学-眼科学] 10[医学]
摘 要：PURPOSE: To identify the speed of corneal neovascularization (CNV) after penetrating keratoplasty (PK) and to evaluate the influence of surgery-related factors on postkeratoplasty CNV in keratoconus patients. DESIGN: Prospective, longitudinal, observational, case series study. METHODS: All consecutive primary PKs performed for keratoconus by four experienced surgeons between January 1, 2000 and December 31, 2002 at our department were included (n=66 patients). Standardized corneal photographs taken preoperatively and at 6 weeks, 3, 6, 12, 18, and 24 months postoperatively were evaluated. Limbus suture distance (LSD), limbus graft distance (LGD), inner suture angle (ISA), and maximal extension of CNVs in digitized pictures with 100-fold magnification were measured at each of the 16 suture turning points at every timepoint. RESULTS: Forty-four (67%) out of 66 corneal grafts developed some degree of CNV after PK, most commonly from around the 12 o’clock position. The mean speed of CNVgrowth was 114 μm/month with the fastest growth occurring during the first six weeks after PK. There was an inverse correlation between CNV and LSD, LGD, and ISA (all P .001). Ninety percent of all CNVs developed with LSD 406 μm and with LGD 1000 μm. Superior limbal localization between 11 and 1 o’clock is an independent risk factor for postoperative neovascularization, too (P .001). CONCLUSIONS: Small LSD, small LGD, and narrow stitching with small ISA were identified as potentially modifiable surgical risk factors for CNVafter PK. The speed of CNV outgrowth was most pronounced in the first weeks after PK making early postoperative controls for CNV growth and initiation of antiangiogenic treatment important.
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