Clinical relevance of intestinal barrier dysfunction in common gastrointestinal diseases
作者机构：ImmunicAGGräfelfing 82166Germany
出 版 物：《World Journal of Gastrointestinal Pathophysiology》 (世界胃肠病理生理学杂志（英文版）（电子版）)
年 卷 期：2020年第11卷第6期
页 面：114-130页
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
主 题：Intestinal barrier Microbiome Gastrointestinal disease Inflammatory bowel disease Inflammatory bowel syndrome Colitis
摘 要：The intestinal barrier is a complex and well-controlled physiological construct designed to separate luminal contents from the bowel *** this review,we focus on the intestinal barrier’s relationship with the host’s immune system interaction and the external environment,specifically the *** bowel allows the host to obtain nutrients vital to survival while protecting itself from harmful pathogens,luminal antigens,or other pro-inflammatory *** over barrier function and the luminal milieu is maintained at the biochemical,cellular,and immunological ***,disruption to this highly regulated environment can cause *** advances to the field have progressed the mechanistic understanding of compromised intestinal barrier function in the context of gastrointestinal *** are numerous examples where bowel barrier dysfunction and the resulting interaction between the microbiome and the immune system has disease-triggering *** purpose of this review is to summarize the clinical relevance of intestinal barrier dysfunction in common gastrointestinal and related *** may help highlight the importance of restoring barrier function as a therapeutic mechanism of action in gastrointestinal pathology.
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