Whole-Brain Map of Long-Range Monosynaptic Inputs to Different Cell Types in the Amygdala of the Mouse

作     者：Jia-Yu Fu Xiao-Dan Yu Yi Zhu Shi-Ze Xie Meng-Yu Tang Bin Yu Xiao-Ming Li Jia-Yu Fu;Xiao-Dan Yu;Yi Zhu;Shi-Ze Xie;Meng-Yu Tang;Bin Yu;Xiao-Ming Li

作者机构：Center for Neuroscience and Department of Neurology of Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310058China NHC and CAMS Key Laboratory of Medical NeurobiologyCenter for Brain Science and Brain-Inspired IntelligenceGuangdong-Hong Kong-Macao Greater Bay AreaJoint Institute for Genetics and Genome Medicine between Zhejiang University and University of TorontoHangzhou 310058China 

出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)

年 卷 期：2020年第36卷第11期

页      面：1381-1394页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 07[理学] 1001[医学-基础医学(可授医学、理学学位)] 071006[理学-神经生物学] 

基　　金：the Key Project of the National Natural Science Foundation of China(31430034) the National Key Research and Development Project of the Ministry of Science and Technology of China(2016YF051000) the Science and Technology Program of Guangdong Province,China(2018B030334001) the Key Realm R&D Program of Guangdong Province,China(2019B030335001) Funds for Creative Research Groups of China from the National Natural Science Foundation of China(81521062) the Non-Profit Central Research Institute Fund of the Chinese Academy of Medical Sciences(2019PT310023)。 

主　　题：Basolateral amygdala Central amygdala Rabies virus retrograde tracing Glutamatergic GABAergic Mouse 

摘      要：The amygdala,which is involved in various behaviors and emotions,is reported to connect with the whole brain.However,the long-range inputs of distinct cell types have not yet been defined.Here,we used a retrograde trans-synaptic rabies virus to generate a whole-brain map of inputs to the main cell types in the mouse amygdala.We identified 37 individual regions that projected to neurons expressing vesicular glutamate transporter 2,78 regions to parvalbumin-expressing neurons,104 regions to neurons expressing protein kinase C-δ,and 89 regions to somatostatin-expressing neurons.The amygdala received massive projections from the isocortex and striatum.Several nuclei,such as the caudate-putamen and the CA1 field of the hippocampus,exhibited input preferences to different cell types in the amygdala.Notably,we identified several novel input areas,including the substantia innominata and zona incerta.These findings provide anatomical evidence to help understand the precise connections and diverse functions of the amygdala.