Influence of lymph node micrometastasis on the staging system for gastric cancer

作     者：Lixiong Gao Xiankun Ren Guiquan Li Benhua Wu Xuan Chen Lixiong Gao;Xiankun Ren;Guiquan Li;Benhua Wu;Xuan Chen

作者机构：Department of GastroenterologyMedical Center Hospital of QionglaiQionglai 611530China Department of GastroenterologyThe Affiliated Hospital of Southwest Medical UniversityLuzhou 646000China 

出 版 物：《Oncology and Translational Medicine》 (肿瘤学与转化医学（英文版）)

年 卷 期：2020年第6卷第6期

页      面：266-271页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by a grant from the scientific research project of Sichuan Health Committee(No.19pj045) 

主　　题：gastric cancer lymph node micrometastasis TNM stage 

摘      要：Objective The aim of this study was to investigate the effect of lymph node micrometastasis on the prognosis of patients with gastric cancer and the necessity of integrating it into the gastric cancer staging *** In total,241 patients with gastric cancer were *** and eosin staining of lymph nodes was performed,and negative lymph nodes were evaluated by immunohistochemistry to detect *** in survival rates between stages were ***(1)A total of 78 patients(32.4%)had lymph node *** with the group without micrometastases,the overall recurrence rate,lymph infiltration,vascular invasion,and nerve invasion rate in the micrometastasis group were significantly higher(P0.05).(2)According to the standard N staging system,the rates of disease-free survival(DFS)for the N0,N1,N2,N3a,and N3b groups were 96.0%,84.0%,67.6%,59.0%,and 21.7%,*** was no significant difference in survival between N2 and *** cumulative survival curves for N2 and N3a intersected.(3)The N stage of 38 patients(15.8%)differed between the traditional system and the new N staging system reflecting *** DFS for N0,N1,N2,N3a,and N3b were 97.0%,86.3%,74.2%,65.4%,and 29.2%,*** was no significant difference in survival between N2 and N3a,but the cumulative survival curves for N2 and N3a did not intersect.(4)Based on a Cox multivariate analysis,various independent risk factors for recurrence were identified(P0.05).Conclusion Lymph node micrometastasis is an important risk factor for gastric cancer *** node micrometastasis should be considered in TNM staging to determine prognosis and optimal treatment strategies.