O-GIcNAc transferase regulates centriole behavior and intraflagellar transport to promote ciliogenesis
作者机构：Department of Genetics and Cell BiologyCollege of Lifle SciencesState Key Laboratory of Medicinal Chemical BiologyTanjin Key Laboratory of Protein ScienceKey Laboratory of Bioactive Materials of the Ministry of EducationNankai UniversilyTianjin 300071China College of PharmacyState Key Laboratory of Medicinal Chemical BiologyNankai UniyersityTianjin 300071China State Key Laboratory of Cell BiologyShanghai Insttute of Biochemistry and Cell BiologyCenter for Excel lence in Molecular Cell ScienceChinese Academy of SciencesShanghai 200031China University of Chinese Academy of SciencesBeijing 100049China Institute of Biomedical SciencesShandong Provincial Key Lab-oratory of Animal Resistance BiologyCollaboralive Innovation Center of Cell Biology in Universities of ShandongCollge of Life Sciences.Shandong Nomal UniversityJinan 250014China
出 版 物：《Protein & Cell》 (蛋白质与细胞（英文版）)
年 卷 期：2020年第11卷第11期
页 面：852-857页
核心收录：
学科分类：0710[理学-生物学] 07[理学] 071009[理学-细胞生物学]
基 金：We thank Dr.Wen Ning for providing the Ube-Cre-ERT2 mice.This work was supported by grants from the National Key R&D Program of China(2017YFA0503502) the National Natural Science Foundation of China(31991193).Fan Yu,Te Li。Yanchao Sui,Qingxia Chen,Song Yang,Jia Yang,Renjie Hong,Dengwen they have no conflict of interest.All institutional and national guidelines for the care and use of laboratory animals were fllowed.Li,Xiumin Yan,Wei Zhao,Xueliang Zhu,and Jun Zhou declare that。
摘 要：Dear Editor,O-GIcNAcylation is a nutrient sensor that is particularly sensitive to environmental glucose(Hardiville and Hart,2014).Glucose can be converted to UDP-GIcNAc through the hexosamine biosynthetic pathway,providing a substrate for O-GIcNAcylation.Two enzymes participate in this reversible modification,O-GIcNAc transferase(OGT),which adds a single GIcNAc residue to the serine/threonine sites of proteins,and O-GIcNAcase(OGA),which removes the residue(Yang and Qian,2017).
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