Spectrum of esophageal motility disorders in patients with liver cirrhosis

作     者：Mohamed Khalaf Donald Castell Puja Sukhwani Elias 

作者机构：Department of Gastroenterology and HepatologyMedical University of South CarolinaCharlestonSC 29401United States Department of Internal MedicineMedical University of South CarolinaCharlestonSC 29425United States 

出 版 物：《World Journal of Hepatology》 (世界肝病学杂志（英文版）（电子版）)

年 卷 期：2020年第12卷第12期

页      面：1158-1167页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：NIDDK NIH HHS [P30 DK123704] Funding Source: Medline 

主　　题：Esophagus Motility Cirrhosis Dysmotility Gastroesophageal reflux disease Manometry 

摘      要：Disorders of esophageal motility have been described in patients with cirrhosis in a small number of *** this review,we aim to provide an overview of the available evidence on esophageal motility disorders in cirrhosis and their clinical *** review delves into the following concepts:(1)Gastroesophageal reflux disease is common in liver cirrhosis due to many mechanisms;however,when symptomatic it is usually nocturnal and has an atypical presentation;(2)Endoscopic band ligation is better than sclerotherapy in terms of its effect on esophageal motility and seems to correct dysmotilities resulting from the mechanical effect of esophageal varices;(3)Chronic alcoholism has no major effects on esophageal motility activity other than lower esophageal sphincter hypertension among those with alcoholic autonomic neuropathy;(4)An association between primary biliary cholangitis and scleroderma can be present and esophageal hypomotility is not uncommon in this scenario;and(5)Cyclosporin-based immunosuppression in liver transplant patients can have a neurotoxic effect on the esophageal myenteric plexus leading to reversible achalasia-like manifestations.