Advances in the diagnosis and management of acute retinal necrosis

作     者：Casey L.Anthony J.Clay Bavinger Steven Yeh 

作者机构：Department of OphthalmologyEmory Eye CenterAtlantaGAUSA 

出 版 物：《Annals of Eye Science》 (眼科学年鉴（英文）)

年 卷 期：2020年第5卷第3期

页      面：69-76页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This project was supported by the National Eye Institute/National Institutes of Health core grant P30-EY06360(Department of Ophthalmology,Emory University School of Medicine) National Eye Institute of the National Institutes of Health under award RO1 EY029594(SY) The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health or the views or policies of the Department of Health and Human Services,nor does mention of trade names,commercial products,or organizations imply endorsement by the U.S.Government This research was also supported an unrestricted departmental grant from Research to Prevent Blindness,Inc.to the Emory Eye Center,Emory University School of Medicine and Association for Research in Vision and Ophthalmology Mallinckrodt Young Investigator Award(SY) 

主　　题：Acute retinal necrosis(ARN) herpetic retinitis herpesvirus retinal detachment 

摘      要：Acute retinal necrosis(ARN)is a devastating syndrome characterized by panuveitis,retinal necrosis,and a high rate of retinal detachment that may result in poor visual outcomes if not promptly diagnosed and *** is most commonly caused by viruses within the herpesvirus *** include varicella-zoster virus,herpes simplex virus,and cytomegalovirus,and may be promptly diagnosed by polymerase chain reaction testing of aqueous or vitreous *** true incidence of ARN is not known due to its rarity;as a result,clinical treatment is often guided by retrospective case series,case reports,and expert *** of care has evolved over time but currently includes a combination of systemic and intravitreal antiviral in conjunction with topical or oral steroids and surgical therapy as *** therapy may reduce the rate of severe vision loss and increase the rate of visual acuity gain,although further studies are needed in this *** particular for patients with mild to moderate disease,combination therapy may reduce the rate of retinal *** therapies including oral corticosteroid and prophylactic laser barricade are incompletely studied,but corticosteroid in particular,may reduce inflammation,which also is involved in the severe disease pathogenesis observed in *** review discusses the advances in diagnosis and treatment of ARN,including management with combination antiviral medication and surgical interventions.