Seroprevalence of SARS-CoV-2 infections among children visiting a hospital

作     者：Ran Wang Fang Jin Shuhui Cao Hong Yuan Jingchen Qu Jiaqi Zhang Yuxuan Li Xiangpeng Chen Wenqi Song Zhengde Xie Wang Ran;Jin Fang;Cao Shuhui;Yuan Hong;Qu Jingchen;Zhang Jiaqi;Li Yuxuan;Chen Xiangpeng;Song Wenqi;Xie Zhengde

作者机构：Beijing Key Laboratory of Pediatric Respiratory Infectious DiseasesKey Laboratory of Major Diseases in ChildrenMinistry of EducationNational Clinical Research Center for Respiratory DiseasesResearch Unit of Critical Infection in ChildrenChinese Academy of Medical Sciences2019RUO16Laboratory of Infectionand VirologyBeijing Pediatric Research InstituteBeijing Children's HospitalNational Center for Children's HealthCapital Medical UniversityBeijingChina Department of Laboratory MedicineBeijing Children's HospitalNational Center for Children's HealthCapital Medical UniversityBeijingChina 

出 版 物：《Pediatric Investigation》 (儿科学研究（英文）)

年 卷 期：2020年第4卷第4期

页      面：236-241页

学科分类：1002[医学-临床医学] 100202[医学-儿科学] 10[医学] 

基　　金：National Major Science&Technology Project for Control and Prevention of Major Infectious Diseases in China(2017ZX10103004-004) 

主　　题：Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) Coronavirus disease 2019(COVID-19) Antibody Seroprevalence Children 

摘      要：Importance:In this study,we retrospectively investigated the seroprevalence of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)antibodies within serum samples from children in Beijing,*** findings provide preliminary guidance regarding population susceptibility to SARS-CoV-2,which will aid in establishing policy toward coronavirus disease 2019(COVID-19)prevention and ***:To understand the seropositivity of anti-SARS-CoV-2 IgM/IgG antibodies among children in Beijing,China,evaluate the susceptibility of children in Beijing to SARS-CoV-2,and provide prima facie evidence to guide SARS-CoV-2 prevention and ***:IgM/IgG antibody kits(colloidal gold)were used to conduct preliminary screening of SARS-CoV-2 IgM/IgG antibodies in serum samples of children who presented to Beijing Children’s Hospital,Capital Medical University,having fever or requiring hospitalization,from March 2020 to August *** analysis of anti-SARS-CoV-2 antibody seropositivity was performed according to the children’s general demographic characteristics,timing of admission to hospital,presence of pneumonia,and viral nucleic acid test ***:The study included 19797 children with both IgM and IgG antibody ***-four children had anti-SARS-CoV-2 IgM-positive results(positive rate of 1.2‰),twelve children had anti-SARS-CoV-2 IgG-positive results(positive rate of 0.6‰).Viral nucleic acid test results were negative for the above-mentioned children with positive antibody findings;during the study,two children exhibited positive viral nucleic acid test results,but their anti-SARS-CoV-2 IgM/IgG antibody results were ***-SARS-CoV-2 IgM antibody seropositivity was higher in the1-year-old group than in the≥6-year-old *** rates of anti-SARS-CoV-2 IgM seropositivity was highest in August from March to August;IgG results did not significantly differ over *** rates of anti-SARS-CoV-2 IgM or IgG seropositivity among children