Preparation and functionalization of mesoporous silica spheres as packing materials for HPLC

作     者：Liming Yang Yujun Wang Guangsheng Luo Youyuan Dai 

作者机构：The State Key Laboratory of Chemical Engineering Department of Chemical Engineering Tsinghua University Beijing 100084 China 

出 版 物：《Particuology》 (颗粒学报（英文版）)

年 卷 期：2008年第6卷第3期

页      面：143-148页

核心收录：

学科分类：07[理学] 0703[理学-化学] 

基　　金：supports from the National Natural Science Foundation of China(20676066,20525622) the 973 Plan(2007CB714302)on this work 

主　　题：Mesoporous Silica sphere Water-soluble polymer Assembly HPLC 

摘      要：This paper presents the integrated results of a series of new methods for preparing mesoporous silica spheres as high-performance liquid chromatography （HPLC） packing materials. The separation performance of the mesoporous spheres materials has also been determined. Micrometer- sized silica spheres with uniform spherical morphologies and ordered mesostructures were first successfully synthesized by the method employing a water-soluble polymer-assisted assembly. Then the templates for getting ordered mesoporous materials with high-density silanol groups were removed by using hydrothermal oxidation. Finally the silica spheres were functionalized with C8 alkyl groups by surface modification under hydrothermal conditions. The resultant functionalized silica spheres were demonstrated to be excellent oacking materials for HPLC.